The Stat4Onc Annual Symposium is a venue for interdisciplinary dialogue among clinical and quantitative scientists about cancer clinical trials. We seek participation by researchers from academia, industry, and regulatory agencies to share new research, discuss novel ideas, ask questions, and provide solutions for cancer clinical trials. Oncologists and statisticians can exchange views on trial design and conduct, drug development, and translation to patient care. Because of the current COVID-19 pandemic situation, the 4th Stat4Onc Annual Symposium will be help as an online conference. Topics for this symposium include big data and genomics, novel dose-finding designs, umbrella/basket designs, drug combinations, immune-based oncology, and engagement of under-representative population in oncology research.